With the stimulation of many types of cell surface receptors, MAPKs are activated. We have
previously demonstrated an effect of extracellular ATP on ERKs and gonadotropin-induced …

Objective To investigate the specific role of adenosine triphosphate (ATP) in the subsequent
MAPK-induced signaling cascade in human granulosa-luteal cells (hGLCs). Design We …

ATP has been shown to activate the phospholipase C/diacylglycerol/protein kinase C (PKC)
pathway. However, little is known about the downstream signaling events. The present study …

To investigate the role of ATP in ovarian tumorigenesis, the present study examined the
expression of the P2U purinoceptor (P2U-R) and effect of ATP on growth stimulation in pre …

PKC signaling is critical for follicular development and the induction of ovulatory genes
including Pgr, Prkg2, and Cyp11a1 (SCC). We investigated PKC signaling mechanisms in …

The AMP-activated protein kinase (AMPK) is a major regulator of energy metabolism
involved in fatty acid and cholesterol synthesis. In the ovary, cholesterol plays a key role in …

ATP has been shown to activate the mitogen-activated protein kinase (MAPK) signaling
pathway in various systems. However, little is known about the signaling events and the …

We have previously shown that AMP-activated protein kinase (AMPK) can induce the
resumption of meiosis in mouse oocytes maintained in meiotic arrest in vitro. The present …

The present study investigated the activation of mitogen-activated protein kinases (MAPKs)
by a GnRH agonist (GnRHa) in human granulosa-luteal cells (hGLCs). The phosphorylation …

There is convincing evidence that mitogen-activated protein kinase (MAPK) activation is
coupled to both receptor tyrosine kinase and G protein-coupled receptors. The presence of …