Organ transplantation has become a standard life-saving therapy for many causes of end
stage organ failure. Although valuable, it remains hampered by the requirement for, and …

Given the significant morbidity associated with current post-transplant immunosuppressive
regimens, induction of immune tolerance continues to be an important goal of clinical organ …

Abstract Research in Tolerance and Chimerism by Transplant immunologists for over half a
century is akin to the pursuit of the Holy Grail. Animal experiments for inducing tolerance …

The study of tolerance in the clinic can be divided into three areas:(i) focused evaluation of
existing tolerant transplant recipients as to their mechanism of tolerance;(ii) prospective …

Introduction of modern immunosuppressive agents has led to great success of
allotransplantation in humans, and survival rates for all solid organs have been dramatically …

Renal transplantation has become the preferred treatment for end stage kidney failure.
Although short-term graft survival has significantly improved as advances in …

Vascularized allografts are rejected unless some indefinite modification to the recipient's
immune system is made. This modification is typically achieved through the long-term …

Although the reductionist approach has served science well for 400 years, the accumulation
of details can obscure the truth if the original premise is incorrect. One such premise has …

Kawai T, Benedict Cosimi A. Induction of tolerance in clinical kidney transplantation. Clin
Transplant 2010: 24 (Suppl. 22): 2–5.© 2010 John Wiley & Sons A/S. Abstract: Induction of …

The search for tolerance therapies that would thwart the alloimmune response following
organ transplantation while preserving a patient's protective immune response has been a …