Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17
DM Durrant, SL Gaffen, EP Riesenfeld… - The Journal of …, 2009 - journals.aai.org
Dysfunctional expression of T-bet, a transcription factor that is critical for IFN-γ production,
has been implicated in the development of asthma. To investigate in detail the mechanisms …
has been implicated in the development of asthma. To investigate in detail the mechanisms …
T-bet inhibits both TH2 cell–mediated eosinophil recruitment and TH17 cell–mediated neutrophil recruitment into the airways
M Fujiwara, K Hirose, S Kagami, H Takatori… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Previous studies have shown that mice lacking T-bet, a critical transcription
factor for TH1 cell differentiation, spontaneously develop airway inflammation with intense …
factor for TH1 cell differentiation, spontaneously develop airway inflammation with intense …
[HTML][HTML] IL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expression
DM Durrant, DW Metzger - Mucosal immunology, 2010 - Elsevier
Abstract Interleukin (IL)-12 has been shown to suppress T helper type 2 (Th2)-induced
pathogenesis that is associated with allergic asthma, largely through interferon (IFN)-γ …
pathogenesis that is associated with allergic asthma, largely through interferon (IFN)-γ …
IL-25 promotes Th2 immunity responses in airway inflammation of asthmatic mice via activation of dendritic cells
L Hongjia, Z Caiqing, L Degan, L Fen, W Chao… - Inflammation, 2014 - Springer
Allergic asthma occurs as a consequence of inappropriate immunologic inflammation to
allergens and characterized by Th2 adaptive immune response. Recent studies indicated …
allergens and characterized by Th2 adaptive immune response. Recent studies indicated …
Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation …
N Mizutani, H Goshima, T Nabe… - The Journal of …, 2012 - journals.aai.org
Allergen-specific IgE plays an essential role in the pathogenesis of allergic asthma.
Although there has been increasing evidence suggesting the involvement of IL-17 in the …
Although there has been increasing evidence suggesting the involvement of IL-17 in the …
Interleukin-17 regulation: an attractive therapeutic approach for asthma
SJ Park, YC Lee - Respiratory research, 2010 - Springer
Abstract Interleukin (IL)-17 is recognized to play a critical role in numerous immune and
inflammatory responses by regulating the expression of various inflammatory mediators …
inflammatory responses by regulating the expression of various inflammatory mediators …
Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma
PW Hellings, A Kasran, Z Liu… - American journal of …, 2003 - atsjournals.org
Interleukin (IL)-17 is produced by activated memory CD4+ cells and induces cytokines and
chemokines that stimulate neutrophil generation and recruitment. Here, we investigated the …
chemokines that stimulate neutrophil generation and recruitment. Here, we investigated the …
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell–dependent pathway in mice
T Tamachi, Y Maezawa, K Ikeda, S Kagami… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5,
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune …
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune …
Interaction of interleukin-17A with a Th2 response in a mouse model of allergic airway inflammation
K Peters, S Ernst, M Peters - Cells, 2023 - mdpi.com
Background: A total of 262 million people worldwide suffer from asthma and 461000 people
died from it in 2019. Asthma is a disease with different endotypes defined by the …
died from it in 2019. Asthma is a disease with different endotypes defined by the …
Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice
P Chenuet, L Fauconnier, F Madouri, T Marchiol… - Clinical …, 2017 - portlandpress.com
T helper (Th) 17 immune response participates in allergic lung inflammation and asthma is
reduced in the absence of interleukin (IL)-17 in mice. Since IL-17A and IL-17F are induced …
reduced in the absence of interleukin (IL)-17 in mice. Since IL-17A and IL-17F are induced …