Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter-driven gene expression

Z Redshaw, AJ Strain - Journal of negative results in biomedicine, 2010 - Springer
The transcription factor Oct4 is well defined as a key regulator of embryonic stem (ES) cell
pluripotency. In recent years, the role of Oct4 has purportedly extended to the self renewal …

Oct‐4A isoform is expressed in human cord blood‐derived CD133 stem cells and differentiated progeny

M Howe, J Zhao, Y Bodenburg, CP McGuckin… - Cell …, 2009 - Wiley Online Library
Objectives: This study aims to establish whether the pluripotent embryonic stem cell marker
and nuclear transcription factor Oct‐4A isoform is expressed in human umbilical cord blood …

Revisiting OCT4 expression in peripheral blood mononuclear cells

V Kotoula, SI Papamichos, AF Lambropoulos - Stem cells, 2008 - academic.oup.com
The transcription factor OCT4 (officially POU5F1; alternatively OCT3, OCT3/4, OTF3, and
OTF4) is currently considered a main regulator of human embryonic stem cell pluripotency …

Oct‐4 expression in adult human differentiated cells challenges its role as a pure stem cell marker

S Zangrossi, M Marabese, M Broggini, R Giordano… - Stem …, 2007 - academic.oup.com
The Oct‐4 transcription factor, a member of the POU family that is also known as Oct‐3 and
Oct3/4, is expressed in totipotent embryonic stem cells (ES) and germ cells, and it has a …

OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells

Y Atlasi, SJ Mowla, SAM Ziaee, PJ Gokhale… - Stem …, 2008 - academic.oup.com
OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially
encode two spliced variants, designated OCT4A and OCT4B. We have examined the …

Oct4 and its pseudogenes confuse stem cell research

S Liedtke, J Enczmann, S Waclawczyk, P Wernet… - Cell stem cell, 2007 - cell.com
Octamer-binding transcription factor 4 (Oct4) encodes a POU-domain transcription factor
(Scholer et al., 1990). The gene is specifically expressed in embryonic stem (ES) cells but …

Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency

SC Tsai, DF Chang, CM Hong, P Xia… - … of Physiology-Cell …, 2014 - journals.physiology.org
Our knowledge of the molecular mechanisms underlying human embryonic stem cell
(hESC) self-renewal and differentiation is incomplete. The level of octamer-binding …

OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB–MSCs)

KW Seo, SR Lee, DR Bhandari, KH Roh… - Biochemical and …, 2009 - Elsevier
The OCT4A gene, a POU homeodomain transcription factor, has been shown to be
expressed in embryonic stem cells (ESC) as well as hUCB–MSCs. In this study, the roles …

Concise Review: Isoforms of OCT4 Contribute to the Confusing Diversity in Stem Cell Biology

X Wang, J Dai - Stem cells, 2010 - academic.oup.com
The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

OCT4 pseudogenes present in human leukemia cells

X Guo, Y Tang - Clinical and experimental medicine, 2012 - Springer
The transcription factor OCT4 is expressed in embryonic stem cells (ESCs) and has been
considered as a main regulator in maintaining pluripotency of ESCs. Several studies have …