Pluripotent embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid
response to differentiation cues. The identification of genes maintaining ESC identity is …

Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered
on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have …

Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid
response to differentiation cues. Both ESC features are subject to epigenetic regulation …

A fundamental goal in biology is to understand the molecular basis of cell identity.
Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors …

Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal
maintenance and application of embryonic stem cells (ESCs). While the protein-protein …

Background The FACT complex is a conserved histone chaperone with critical roles in
transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but …

The pluripotency of human embryonic stem cells (hESC) could have great potential for the
development of cell replacement therapies. Previous studies have converged on the finding …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long
lasting question whether some of the somatic cells retains totipotency was answered by the …