Embryonic stem cells (ESCs) are pluripotent cells, which can be isolated from the inner cell
mass (ICM) of blastocyst stage embryos. They are defined by two properties: they can …

Pluripotency and self-renewal are the defining traits of embryonic stem cells (ESCs) and this
status quo is maintained by the core transcription factors Oct4, Sox2, and Nanog. Genome …

Oct4 and Sox2 are transcription factors required for pluripotency during early
embryogenesis and for the maintenance of embryonic stem cell (ESC) identity. Functional …

To fully understand self-renewal and pluripotency and their regulation in human embryonic
stem cells (hESCs), it is necessary to generate genetically modified cells and analyze the …

Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered
on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have …

Human pluripotent stem cells (hPSCs) have the ability to self-renew indefinitely in culture, as
well as differentiate towards somatic cells and extraembryonic tissues in appropriate culture …

The Oct4 gene is a master regulator of the pluripotent properties of embryonic stem cells
(ESCs). Recently, Oct4 loci were shown to frequently localize in close proximity to one …

Objective: OCT4 is a master regulator of self-renewal and involved in regulating pluripotency
in embryonic stem cells (ESCs). In addition to the previously described spliced variants of …

The transcription factors OCT4 and SOX2 are required for generating induced pluripotent
stem cells (iPSCs) and for maintaining embryonic stem cells (ESCs). OCT4 and SOX2 …