Background The transcription factor OCT4 is highly expressed in pluripotent embryonic stem
cells which are derived from the inner cell mass of mammalian blastocysts. Pluripotency and …

Oct4 is considered a key transcription factor for pluripotent stem cell self-renewal. It binds to
specific regions within target genes to regulate their expression and is downregulated upon …

A fundamental goal in biology is to understand the molecular basis of cell identity.
Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors …

Abstract Pluripotency factors Oct4, Sox2, and Nanog orchestrate an elaborate hierarchy of
gene regulation governing embryonic stem cell (ESC) identity. The capability of …

The transcription factor Oct4 is essential for the maintenance and induction of stem cell
pluripotency, but its functional roles are not fully understood. Here, we investigate the …

In this chapter we will discuss the data published regarding expression of two key ESC
transcription factors, Oct4 and Nanog, in adult stem cells. In an introduction, we will discuss …

Objective: OCT4 is a master transcriptional regulator, which mediates pluripotency in
embryonic stem cells (ESCs) through inhibition of tissue-specific and promotion of stem cell …

Embryonic stem (ES) cells have therapeutic potential in regenerative medicine, although the
molecular mechanism controlling their pluripotency is not completely understood …

OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially
encode two spliced variants, designated OCT4A and OCT4B. We have examined the …

We have examined the gene structure and regulatory regions of octamer-binding
transcription factor 3/4 (Oct 3/4), sex determining region Y box 2 (Sox2), signal transducer …