Embryonic Stem Cells (ESCs) are subject of intense research. These cells derived from the
Inner Cell Mass (ICM) of the early blastocyst can be propagated indefinitely in vitro while …

OCT4 was discovered more than two decades ago as a transcription factor specific to early
embryonic development. Early studies with OCT4 were descriptive and looked at …

The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early
mammalian embryo and is highly expressed in the inner cell mass of the blastocyst …

Since the successful isolation of mouse and human embryonic stem cells (ESCs) in the past
decades, massive investigations have been conducted to dissect the pluripotency network …

Since its discovery as a critical regulator of pluripotency in embryonic stem (ES) cells and
the inner cells mass of the developing blastocyst, the Pou domain-containing transcription …

Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as
well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem …

The Oct4 transcription factor is essential for the self‐renewal and pluripotency of embryonic
stem cells (ESCs). Oct4 level also controls the fate of ESCs. We analyzed the effects of Oct4 …

The pluripotency factor OCT4 is essential for the maintenance of naive pluripotent stem cells
in vitro and in vivo. However, the specific role of OCT4 in this process remains unknown …

Oct4 has been implicated in regulation of pluripotency in embryonic stem cells (ESCs) and
reprogramming of somatic cells into induced pluripotent stem cells. However, the molecular …

Embryonic stem (ES) cell pluripotency is governed by OCT4-centric transcriptional networks.
Conventional ES cells can be derived and maintained in vitro with media containing the …