Human embryonic stem (hES) cells, derived from blastocysts, are capable of unlimited self-
renewal and differentiation into all cell lineages of the body. Because of their pluripotent …

The cytokine LIF and its downstream effector STAT3 are essential for maintenance of
pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell …

Evaluation of: Gu P, Le Menuet D, Chung AC-K, Cooney AJ: Differential recruitment of
methylated CpG binding proteins by the orphan receptor GCNF initiates the repression and …

The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is
dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through …

Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-
renewal, pluripotency, and somatic cell reprogramming. However, limited information is …

Oct4 is a member of the OCT protein family. The Oct-4gene encodes a transcription factor
that isspecifically expressed in embryonic stem cells and germ cells ofthe mouse embryo …

OCT4 is a master transcriptional regulator, which mediates pluripotency in ESCs through
inhibition of tissue-specific and promotion of stem cell-specific genes. Suppression of OCT4 …

Pluripotent cells have the potential to differentiate into all of the cell types of an animal. This
unique cell state is governed by an interconnected network of transcription factors. Among …

Background Oct4 is a key factor of an expanded transcriptional network (Oct4-TN) that
governs pluripotency and self-renewal in embryonic stem cells (ESCs) and in the inner cell …

Mouse and human ES (embryonic stem) cells display unusual proliferative properties and
can produce pluripotent stem cells indefinitely. Both processes might be important for …