IDENTIFICATION OF OCT4 AND SOX2 TARGETS IN MOUSE EMBRYONIC STEM CELLS
CHEW JOON LIN A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR Page 1 …

Embryonic stem cells and induced pluripotent stem cells provided us with fascinating new
knowledge in recent years. Mechanistic insight into intricate regulatory circuitry governing …

The cytokine LIF and its downstream effector STAT3 are essential for maintenance of
pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell …

Sox2 and Oct4 partner to regulate the transcription of many genes in the pluripotent lineage
through binding composite Sox-Oct cis-regulatory elements (SO-CREs). While sequence …

Although it is known that OCT4–NANOG are required for maintenance of pluripotent cells in
vitro, the upstream signals that regulate this circuit during early development in vivo have not …

During the past 10 years, remarkable progress has been made in understanding the
transcriptional mechanisms that control the biology of stem cells. Given the importance of …

Human embryonic stem cells (hESCs) are capable of infinite proliferation and hold the
potential to differentiate into various cell lineages for cell and tissue transplantation. Many …

Embryonic stem cells (ESCs) are defined by their simultaneous capacity for limitless self-
renewal and the ability to specify cells borne of all germ layers. The regulation of ESC …

Abstract INTRODUCTION: TOTIPOTENCY REFERS TO AN ABILITY OF A SINGLE CELL TO
DIVIDE AND PRODUCE ALL OF THE DIFFERENTIATED CELLS IN AN ORGANISM. IN …

OCT4 is considered a main regulator of embryonic stem cell pluripotency and self renewal
capacity. It was shown that relevant OCT4 expression only occurs in cells of embryonic …