Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids,
presented by the non‐classical CD 1 family (CD 1a–e). These molecules have evolved …

It is well established that different populations of αβ T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules, but also foreign and self-lipids …

NKT cells are immunoregulatory lymphocytes whose activation is triggered by the
recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we …

Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

Over the past ten years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins,
which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of …

Plasma membranes of eukaryotic cells are not uniform, possessing distinct cholesterol-and
sphingolipid-rich lipid raft microdomains which constitute critical sites for signal transduction …

The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex
(MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T …

αβ T cell receptors (TCRs) have traditionally been viewed as receptors for peptide antigens
presented by either Major Histocompatibility Complex (MHC) class I (for CD8 T cells) or …

Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to
probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies …