Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
KK Waltering, MA Helenius, B Sahu, V Manni, MJ Linja… - Cancer research, 2009 - AACR
Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate
cancer. To interrogate the functional significance of the AR level, we established two LNCaP …
cancer. To interrogate the functional significance of the AR level, we established two LNCaP …
Identification of novel androgen receptor target genes in prostate cancer
U Jariwala, J Prescott, L Jia, A Barski, S Pregizer… - Molecular cancer, 2007 - Springer
Background The androgen receptor (AR) plays critical roles in both androgen-dependent
and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes …
and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes …
Expression, structure, and function of androgen receptor in advanced prostatic carcinoma
Z Culig, A Hobisch, A Hittmair, H Peterziel… - The …, 1998 - Wiley Online Library
BACKGROUND Endocrine therapy for prostate cancer aims to reduce the levels of
circulating androgen or to inhibit androgen action by blocking the androgen receptor in the …
circulating androgen or to inhibit androgen action by blocking the androgen receptor in the …
Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate
cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin …
cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin …
Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
MJ Linja, KJ Savinainen, OR Saramäki, TLJ Tammela… - Cancer research, 2001 - AACR
The expression level of the androgen receptor (AR) gene in androgen-dependent and-
independent prostate cancer was determined by using real-time quantitative reverse …
independent prostate cancer was determined by using real-time quantitative reverse …
Alterations of androgen receptor in prostate cancer
MJ Linja, T Visakorpi - The Journal of steroid biochemistry and molecular …, 2004 - Elsevier
The significance of androgens in the development of prostate cancer has been known for
more than half century. During the last decade, a lot of effort has been put to study the …
more than half century. During the last decade, a lot of effort has been put to study the …
Androgen receptor–an update of mechanisms of action in prostate cancer
Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is
expressed in all histological types and stages of prostate cancer. The AR regulates …
expressed in all histological types and stages of prostate cancer. The AR regulates …
Androgen receptor action in hormone‐dependent and recurrent prostate cancer
IU Agoulnik, NL Weigel - Journal of cellular biochemistry, 2006 - Wiley Online Library
The importance of androgens and androgen receptors (AR) in primary prostate cancer is
well established. Metastatic disease is usually treated with some form of androgen ablation …
well established. Metastatic disease is usually treated with some form of androgen ablation …
Androgen receptors in prostate cancer
PURPOSE: Androgen receptor (AR) is expressed in the majority of human prostate cancers.
For a better understanding of prostate carcinoma events it is necessary to present findings …
For a better understanding of prostate carcinoma events it is necessary to present findings …
Androgen receptor signaling in prostate cancer
The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …