Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical presentations of
frontotemporal dementia (FTD), including progressive changes in behavior, personality …

Frontotemporal dementia (FTD) is typified by behavioral and cognitive changes manifested
as altered social comportment and impaired memory performance. To investigate the …

Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in
individuals under age 60 and has no treatment or cure. Because many cases of FTD result …

Mutations in the progranulin (GRN) gene represent about 5–10% of frontotemporal lobar
degeneration (FTLD). We describe a proband with a novel GRN mutation c. 687T> A …

Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology
and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …

Mutations in progranulin gene (GRN) are a common cause of autosomal dominant
frontotemporal lobar degeneration and are associated with a wide phenotypic …

Heterozygous loss-of-function (LOF) mutations in the human progranulin gene (GRN) cause
frontotemporal lobar degeneration (FTLD) by a mechanism of haploinsufficiency. Patients …

Progranulin (GRN) mutations are a major cause of frontotemporal dementia (FTD); the
spectrum of clinical phenotypes of FTD is much more extensive than previously reported …

Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …