CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM 2, neurodegeneration and cognitive decline
M Suárez‐Calvet, A Capell… - EMBO molecular …, 2018 - embopress.org
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …
[HTML][HTML] Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
S Miyakawa, H Sakuma, D Warude… - Frontiers in …, 2020 - frontiersin.org
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase
A Capell, S Liebscher, K Fellerer… - Journal of …, 2011 - Soc Neuroscience
Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal
lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by …
lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by …
[HTML][HTML] Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
S Hasan, MS Fernandopulle, SW Humble… - Molecular …, 2023 - Springer
Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various
neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid …
neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid …
Modifiers of GRN-associated frontotemporal lobar degeneration
E Wauters, S Van Mossevelde, J Van der Zee… - Trends in molecular …, 2017 - cell.com
Heterozygous loss-of-function (LOF) mutations in the human progranulin gene (GRN) cause
frontotemporal lobar degeneration (FTLD) by a mechanism of haploinsufficiency. Patients …
frontotemporal lobar degeneration (FTLD) by a mechanism of haploinsufficiency. Patients …
[HTML][HTML] Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
MM Carrasquillo, AM Nicholson, NC Finch… - The American Journal of …, 2010 - cell.com
Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function
mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD), a …
mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD), a …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
[HTML][HTML] Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
MC Chang, K Srinivasan, BA Friedman… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN …
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
[HTML][HTML] Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
J Frew, A Baradaran-Heravi, AD Balgi, X Wu… - Molecular …, 2020 - Springer
Background Frontotemporal lobar degeneration (FTLD) is a devastating and progressive
disorder, and a common cause of early onset dementia. Progranulin (PGRN) …
disorder, and a common cause of early onset dementia. Progranulin (PGRN) …