The Plasmodium falciparum protein VAR2CSA allows infected erythrocytes to accumulate
within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to …

Plasmodium falciparum malaria remains one of the world's foremost health problems,
primarily in highly endemic regions such as Sub-Saharan Africa, where it is responsible for …

Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum
parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite …

Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the
interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA …

Background Protection against pregnancy associated malaria (PAM) is associated with high
levels of anti-VAR2CSA antibodies. This protection is obtained by the parity dependent …

Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …

Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …

The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the
infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the …

Pregnancy-associated malaria is a major health problem, which mainly affects primigravidae
living in malaria endemic areas. The syndrome is precipitated by accumulation of infected …

In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated
by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on …