Down-regulation of chemokine Ccl5 gene expression in the NTS of SHR may be pro-hypertensive

SS Gouraud, H Waki, MER Bhuiyan… - Journal of …, 2011 - journals.lww.com
Objectives Recent studies have demonstrated that pro-inflammatory molecules such as
junctional adhesion molecules-1 are highly expressed in the nucleus tractus solitarii (NTS) …

Evidence of specific inflammatory condition in nucleus tractus solitarii of spontaneously hypertensive rats

H Waki, SS Gouraud, M Maeda, JFR Paton - 2010 - Wiley Online Library
Since the nucleus tractus solitarii (NTS) is a pivotal region for regulating the set‐point of
arterial pressure, we proposed a role for it in the development of neurogenic hypertension …

Specific inflammatory condition in nucleus tractus solitarii of the SHR: novel insight for neurogenic hypertension?

H Waki, SS Gouraud, M Maeda, JFR Paton - Autonomic Neuroscience, 2008 - Elsevier
Human essential hypertension is a complex polygenic trait with underlying genetic
components that remain unknown. Since the brainstem structure—the nucleus of the solitary …

Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat

H Waki, SS Gouraud, M Maeda, JFR Paton - Autonomic Neuroscience, 2008 - Elsevier
Since the nucleus of the solitary tract (NTS) is a pivotal region for regulating the set-point of
arterial pressure, we proposed a role for it in the development of neurogenic hypertension …

Is neurogenic hypertension related to vascular inflammation of the brainstem?

JFR Paton, H Waki - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
Essential hypertension is idiopathic although it is accepted as a complex polygenic trait with
underlying genetic components, which remain unknown. Our supposition is that …

Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction

L Wang, XC Zhao, W Cui, YQ Ma, HL Ren, X Zhou… - Circulation, 2016 - Am Heart Assoc
Background: The recruitment of leukocytes to the vascular wall is a key step in hypertension
development. Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in …

Blood pressure regulation by CCR genes

M Mettimano, M Lucia Specchia… - Clinical and …, 2006 - Taylor & Francis
New genetic evidence strongly supports a role for the immune system in the pathogenesis of
essential hypertension (EH) through chemokines and their receptors (CCR) involvement …

Upregulation of interleukin-8/CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats

HY Kim, YJ Kang, IH Song, HC Choi, HS Kim - Hypertension Research, 2008 - nature.com
Chemokines promote vascular inflammation and play a pathogenic role in the development
and maintenance of hypertension. In the present study, the expression of the chemokine …

Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats

YH Yun, HY Kim, BS Do, HS Kim - Hypertension Research, 2011 - nature.com
Abstract Angiotensin II (Ang II) exerts some of its effects on the vasculature by stimulating
chemokines and 12-lipoxygenase (12-LO). In addition, a high expression of chemokines by …

High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension

A Antonelli, P Fallahi, SM Ferrari… - International journal …, 2012 - journals.sagepub.com
Hypertension has been suggested to exert pro-inflammatory actions through increased
expression of several mediators, including chemokines. Chemokines are involved in …