Metabolic flux analysis and metabolic engineering of microorganisms
Recent advances in metabolic flux analysis including genome-scale constraints-based flux
analysis and its applications in metabolic engineering are reviewed. Various computational …
analysis and its applications in metabolic engineering are reviewed. Various computational …
Flux balance analysis: interrogating genome-scale metabolic networks
Flux balance analysis (FBA) is a computational method to analyze reconstructions of
biochemical networks. FBA requires the formulation of a biochemical network in a precise …
biochemical networks. FBA requires the formulation of a biochemical network in a precise …
Metabolic flux analysis and visualization
One of the ultimate goals of systems biology research is to obtain a comprehensive
understanding of the control mechanisms of complex cellular metabolisms. Metabolic Flux …
understanding of the control mechanisms of complex cellular metabolisms. Metabolic Flux …
Systems-level analysis of genome-scalein silico metabolic models using MetaFluxNet
The systems-level analysis of microbes with myriad of heterologous data generated by
omics technologies has been applied to improve our understanding of cellular function and …
omics technologies has been applied to improve our understanding of cellular function and …
Kinetic, metabolic, and statistical analytics: addressing metabolic transport limitations among organelles and microbial communities
C Zuniga, JD Tibocha-Bonilla… - Current Opinion in …, 2021 - Elsevier
Highlights•Kinetic, metabolic, and statistical approaches can be combined to unravel
metabolism.•New transport genes controlling organelles metabolic exchange are …
metabolism.•New transport genes controlling organelles metabolic exchange are …
Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics
The increasing availability of metabolomics data necessitates novel methods for deeper
data analysis and interpretation. We present a flux balance analysis method that allows for …
data analysis and interpretation. We present a flux balance analysis method that allows for …
The JBEI quantitative metabolic modeling library (jQMM): a python library for modeling microbial metabolism
Background Modeling of microbial metabolism is a topic of growing importance in
biotechnology. Mathematical modeling helps provide a mechanistic understanding for the …
biotechnology. Mathematical modeling helps provide a mechanistic understanding for the …
A metabolite-centric view on flux distributions in genome-scale metabolic models
SA Riemer, R Rex, D Schomburg - BMC systems biology, 2013 - Springer
Background Genome-scale metabolic models are important tools in systems biology. They
permit the in-silico prediction of cellular phenotypes via mathematical optimisation …
permit the in-silico prediction of cellular phenotypes via mathematical optimisation …
How reliable are Chinese hamster ovary (CHO) cell genome‐scale metabolic models?
B Strain, J Morrissey, A Antonakoudis… - Biotechnology and …, 2023 - Wiley Online Library
Genome‐scale metabolic models (GEMs) possess the power to revolutionize bioprocess
and cell line engineering workflows thanks to their ability to predict and understand whole …
and cell line engineering workflows thanks to their ability to predict and understand whole …
A Method to Constrain Genome-Scale Models with 13C Labeling Data
H García Martín, VS Kumar, D Weaver… - PLoS computational …, 2015 - journals.plos.org
Current limitations in quantitatively predicting biological behavior hinder our efforts to
engineer biological systems to produce biofuels and other desired chemicals. Here, we …
engineer biological systems to produce biofuels and other desired chemicals. Here, we …