Recent advances in metabolic flux analysis including genome-scale constraints-based flux
analysis and its applications in metabolic engineering are reviewed. Various computational …

Flux balance analysis (FBA) is a computational method to analyze reconstructions of
biochemical networks. FBA requires the formulation of a biochemical network in a precise …

One of the ultimate goals of systems biology research is to obtain a comprehensive
understanding of the control mechanisms of complex cellular metabolisms. Metabolic Flux …

The systems-level analysis of microbes with myriad of heterologous data generated by
omics technologies has been applied to improve our understanding of cellular function and …

Highlights•Kinetic, metabolic, and statistical approaches can be combined to unravel
metabolism.•New transport genes controlling organelles metabolic exchange are …

The increasing availability of metabolomics data necessitates novel methods for deeper
data analysis and interpretation. We present a flux balance analysis method that allows for …

Background Modeling of microbial metabolism is a topic of growing importance in
biotechnology. Mathematical modeling helps provide a mechanistic understanding for the …

Background Genome-scale metabolic models are important tools in systems biology. They
permit the in-silico prediction of cellular phenotypes via mathematical optimisation …

Genome‐scale metabolic models (GEMs) possess the power to revolutionize bioprocess
and cell line engineering workflows thanks to their ability to predict and understand whole …

Current limitations in quantitatively predicting biological behavior hinder our efforts to
engineer biological systems to produce biofuels and other desired chemicals. Here, we …