Baculovirus interactions with host cells range from the physical interactions that occur during
viral binding and entry, to the complex and subtle mechanisms that reculate host gene …

Significant progress in the application of baculoviral vectors for gene delivery into
mammalian cells calls for the development of powerful methods for virus purification and …

Baculovirus genomes are covalently closed circles of double stranded-DNA varying in size
between 80 and 180 kilobase-pair. The genomes of more than fourty-one baculoviruses …

The baculovirus expression vector system (BEVS) is widely established as a highly useful
and effective eukaryotic expression system. Thousands of soluble and membrane proteins …

This unit provides information on the replication cycle of insect baculovirus to provide an
understanding of how this virus has been adapted for use as an expression vector for …

Gene therapy in the liver requires powerful vectors capable of mediating sufficient gene
delivery and expression in affected hepatocytes. Viral vectors are amongst the most efficient …

Recombinant baculoviruses carrying mammalian expression cassettes or “BacMam” are
promising gene delivery vehicles shown to transduce mammalian cells efficiently both in …

Baculovirus expression vectors are widely used for expressing heterologous proteins in
cultured insect cells. Recent advances include further development of the system for …

Although recombinant baculovirus vectors can be an efficient tool for gene transfer into
mammalian cells in vitro, gene transduction in vivo has been hampered by the inactivation of …

The baculovirus expression vector system (BEVS) is a versatile and powerful platform for
protein expression in insect cells. With the ability to approach similar post-translational …