Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral
changes and language difficulties. Heterozygous loss-of-function mutations in progranulin …

Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome
17q21. FTD with parkinsonism (FTDP-17) results from mutations in the gene encoding …

Loss-of-function mutations in progranulin (GRN), most of which cause progranulin
haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …

Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal
lobar degeneration (FTLD) and modulates an innate immune response in humans and in …

Loss-of-function mutations in the progranulin gene (GRN) are a common cause of familial
frontotemporal lobar degeneration (FTLD). A high degree of heterogeneity in the age-of …

Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …

Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a
major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) …

Frontotemporal dementia (FTD) is the second most common dementia before 65 years of
age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of …