Background Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative
disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs …

Null mutations in the progranulin gene (PGRN) have been identified as a major cause of
frontotemporal dementia with ubiquitinated inclusions. In this disorder, ubiquitinated …

Loss-of-function mutations in progranulin (GRN) cause ubiquitin-and TAR DNA-binding
protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive …

GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn …

Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration
(FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript …

Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting
the frontal and temporal lobes, is one of the most common types of dementia. While the …

The most common inherited form of Frontotemporal Lobar Degeneration (FTLD) known
stems from Progranulin (GRN) mutation and exhibits TDP-43 plus ubiquitin aggregates …

Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal
lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by …

Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common
cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of …

Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes.
Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive …