Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …

J. Neurochem.(2010) 115, 735–747. Abstract Null mutations in progranulin (GRN) are
associated with frontotemporal lobar degeneration characterized by intraneuronal …

Loss‐of‐function mutations in progranulin (GRN) are a major autosomal dominant cause of
frontotemporal dementia (FTD), a neurodegenerative disorder in which social behavior is …

Introduction Frontotemporal lobar degeneration–causing mutations in the progranulin (GRN)
gene reduce progranulin protein (PGRN) levels, suggesting that restoring PGRN in mutation …

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …

GRN mutations cause progranulin haploinsufficiency, which eventually leads to
frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy delivering …

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration
patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a …

Patients with frontotemporal dementia (FTD) resulting from granulin (GRN)
haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in …

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …

Progranulin (PGRN) is implicated in Alzheimer's disease (AD) as well as frontotemporal
lobar degeneration. Genetic studies demonstrate an association of the common GRN …