Recent advances on differently-expressed gene products and their functions during the
progression from localized androgen-dependent states into androgen-independent and …

A number of molecularly targeted anticancer drugs that efficiently inhibit receptor tyrosine
kinases, socalled receptor tyrosine kinase inhibitors (TKIs), have been developed. Although …

Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent
that most tumours can escape from the inhibition of any single kinase. If it is necessary to …

There are over 200 novel agents currently under evaluation in clinical trials for the treatment
of prostate cancer. Drug development in prostate cancer continues to improve as a better …

The increasing numbers of cancer cases worldwide and the exceedingly high mortality rates
of some tumor subtypes raise the question about if the current protocols for cancer …

Targeted therapeutics are aimed to hit one or a few key cellular targets. Agents that target
single signaling molecules (such as EGFR and IGF-R1) often show limited clinical activities …

Future Med. Chem.(2012) 4 (4) 388 future science group and metastasis and integrate
information such as mutational ana lysis, copy number, geneexpression changes, metabolic …

Receptor tyrosine kinases (RTKs) transduce into the cell a complex network of
environmental signals, orchestrating in a tightly regulated fashion mandatory processes for …

Background Innovative strategies to fully exploit the antitumor activity of multitargeted
tyrosine kinase inhibitors (TKIs) are urgently needed. Higher concentrations of TKIs at their …

Every cell in a multicellular organism receives signals from the extracellular matrix and
neighboring cells. These signals are transmitted, via transmembrane receptors and cascade …