A key tyrosine (Y1494) in the β4 integrin regulates multiple signaling pathways important for tumor development and progression

U Dutta, LM Shaw - Cancer research, 2008 - AACR
Expression of the α6β4 integrin is associated with poor patient prognosis and reduced
survival in a variety of human cancers. In recent years, a limited number of in vivo studies …

[HTML][HTML] Expression of the αvβ6 integrin promotes migration and invasion in squamous carcinoma cells

GJ Thomas, MP Lewis, SA Whawell, A Russell… - Journal of Investigative …, 2001 - Elsevier
The integrin αvβ6 is a fibronectin receptor whose expression is not detectable on normal
oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and …

The integrin α9β1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule …

Y Taooka, J Chen, T Yednock, D Sheppard - The Journal of cell biology, 1999 - rupress.org
The integrin α9β1 has been shown to be widely expressed on smooth muscle and epithelial
cells, and to mediate adhesion to the extracellular matrix proteins osteopontin and tenascin …

A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo

V Bhaskar, D Zhang, M Fox, P Seto, MHL Wong… - Journal of translational …, 2007 - Springer
Background Integrins are important adhesion molecules that regulate tumor and endothelial
cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical …

The role of αv integrins during angiogenesis

BP Eliceiri, DA Cheresh - Molecular medicine, 1998 - Springer
Angiogenesis or vascular remodeling depends on both growth factor stimulation and cell
adhesion events. Angiogenesis and vascular remodeling not only contribute to development …

Integrin αvβ6: Structure, function and role in health and disease

L Koivisto, J Bi, L Häkkinen, H Larjava - The international journal of …, 2018 - Elsevier
Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and
cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules …

Complexes of α6β4 integrin and vimentin act as signaling hubs to regulate epithelial cell migration

ZT Colburn, JCR Jones - Journal of cell science, 2018 - journals.biologists.com
We find that clusters of β4 integrin, organized into distinct puncta, localize along vimentin
filaments within lamellipodia at the cell edge of A549 cells, as assessed by interferometric …

The α3β1 integrin is involved in melanoma cell migration and invasion

A Melchiori, R Mortarini, S Carlone, PC Marchisio… - Experimental cell …, 1995 - Elsevier
The VLA3 (α3β1) integrin receptor recognizes several ligands; however, the function of this
integrin is still debated. Expression of VLA3 appears to be increased in malignant …

TNFα Accelerates Monocyte to Endothelial Transdifferentiation in Tumors by the Induction of Integrin α5 Expression and Adhesion to Fibronectin

B Li, A Pozzi, PP Young - Molecular Cancer Research, 2011 - AACR
Tumor-associated myeloid cells are believed to promote tumor development by stimulating
tumor growth, angiogenesis, invasion, and metastasis. Tumor-associated myeloid cells that …

Integrin alphavbeta6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver

GY Yang, KS Xu, ZQ Pan, ZY Zhang, YT Mi… - Cancer …, 2008 - Wiley Online Library
Integrin alphavbeta6 (αvβ6) is correlated with colon cancer progression. To detect the effects
of αvβ6 on liver metastasis, the specificity of αvβ6 against the monoclonal antibody (mAb) …