The wake-active orexin system plays a central role in the dynamic regulation of glucose
homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in …

Abstract Orexin‐A (hypocretin‐1) and orexin‐B (hypocretin‐2) are hypothalamic
neuropeptides that play key roles in the regulation of wakefulness, feeding, reward …

Initially implicated in the regulation of feeding, orexins/hypocretins are now acknowledged to
play a major role in the control of a wide variety of biological processes, such as sleep …

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Spontaneous physical activity (SPA) describes activity outside of formal exercise and shows
large interindividual variability. The hypothalamic orexin/hypocretin peptides are key …

Orexin-A and-B are two peptides derived by proteolytic cleavage from a 130-amino acid
precursor, prepro-orexin, which were recently isolated from the rat hypothalamus. Orexin-A …

The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous
physical activity (SPA), as lesion or stimulation of this region alters these behaviors …

Abstract Purpose of Review Hypertension is one of the most challenging health problems
inducing cerebrovascular disease and high percentage of death when associated with …

Aims/hypothesis Orexin/hypocretin is a hypothalamic neuropeptide that regulates motivated
behaviours, such as feeding and arousal, and, importantly, is also involved in energy …

Spontaneous physical activity is activity that is non-volitional, or subconscious, such as
fidgeting and shifting in one's seat, and time spent moving (standing and ambulating) …