Objective Sufficient sleep is required for weight maintenance. Sleep deprivation due to noise
exposure stimulates weight gain by increasing hyperphagia and reducing energy …

The finding of orexin (hypocretin) deficiency in patients with narcolepsy suggests that this
hypothalamic neuropeptide plays a crucial role in regulating and maintaining …

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute
pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and …

Orexin/hypocretin terminals innervate noradrenergic locus coeruleus (LC) neurons that
project to the prefrontral cortex, which may influence spontaneous physical activity (SPA) …

Neurohormones are neurosecretory materials released by neurosecretory cells that serve
both as neuromodulators in the brain and spinal cord and as circulating regulatory …

The neuropeptide hypocretin is also commonly referred to as orexin, since its orexigenic
action was recognized early. Orexin/hypocretin (OX) neurons project widely throughout the …

Maintenance of energy homeostasis requires the coordination of systems that regulate
feeding, autonomic and endocrine functions with those that govern an appropriate state of …

The lateral hypothalamic hypocretin (also called orexin) neurons have emerged as
instrumental in triggering arousal and regulating energy metabolism. The lack of hypocretin …

Non-alcoholic steatohepatitis (NASH) occasionally occurs under obesity; however, factors
modulating the natural history of fatty liver disease remain unknown. Since hypothalamic …

Orexin-A and-B are initially identified as endogenous ligands for an orphan G protein
coupled receptor. Since the discovery of orexins, investigations of their functions have been …