Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor
(OX2R) have been shown to play a role in the regulation of feeding, body weight, and …

In this chapter, we give an overview of the current status of the role of orexins in feeding and
energy homeostasis. Orexins, also known as hypocretins, initially were discovered in 1998 …

Consumption beyond homeostatic needs, referred to here as reward-based feeding
behavior, is a central contributor to the current obesity epidemic worldwide. Importantly …

Orexins were initially recognized as regulators of feeding behavior due to their exclusively
production in the lateral hypothalamic area (LHA), a feeding center. Subsequently, the …

Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding,
wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely …

The brain has evolved in an environment where food sources are scarce, and foraging for
food is one of the major challenges for survival of the individual and species. Basic and …

Abstract Orexins (A & B), neuropeptides of hypothalamic origin, act through G-protein
coupled receptors, orexin 1 receptor (OX 1 R) and orexin 2 receptor (OX 2 R). The wide …

The primary role of the orexins was originally believed to be appetite regulation, but is now
believed to be the regulation of sleep, arousal and locomotor activity. Orexin A …

Orexin-A and-B are neuropeptides that are implicated in the regulation of vigilance states
and energy homeostasis. Orexins are specifically produced by neurons located within the …

▪ Abstract Orexin-A and orexin-B are neuropeptides originally identified as endogenous
ligands for two orphan G-protein–coupled receptors. Orexin neuropeptides (also known as …