Prostate cancer is the second most frequently diagnosed cancer worldwide. Hypoxia‐
induced epithelial–mesenchymal transition (EMT), driven by hypoxia‐inducible factor 1α …

Prostate cancer is the most commonly diagnosed cancer in men and the second leading
cause of cancer death. Hypoxia is an environmental stimulus that plays an important role in …

Abstract Hypoxia‑inducible factor (HIF)‑1α has been reported to be associated with
malignancy in a number of types of cancer. However, the role of HIF‑1 α in the regulation of …

Prostate cancer (PCa) has a high incidence worldwide. One of the major causes of PCa
resistance is intratumoral hypoxia. In solid tumors, hypoxia is strongly associated with …

Prostate cancer is the second most common cancer diagnosed in men and the fifth-leading
cause of cancer death in men worldwide. Like any solid tumor, the hypoxic …

Docetaxel is a first-line chemotherapy for the treatment of patients with castration-resistant
prostate cancer (CRPC). Despite the good initial response of docetaxel, drug resistance will …

Background Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients
receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies …

Abstracts Purpose Chemoresistance severely restricts the anti-cancer medicines from
effectively treating human ovarian cancer, which has been shown to develop and survive in …

Hypoxia could enhance radioresistance in prostate cancer cells through up-regulating HIF-
1α, which could be inhibited by statins in several cancer cells. However, this effect of statins …

OBJECTIVE:: The efficacy of docetaxel has recently been shown to be increased under
hypoxic conditions through the down-regulation of hypoxia-inducible-factor 1α (HIF1A) …