Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice

J Shen, R Wan, G Hu, F Wang, J Shen, X Wang - Cytokine, 2012 - Elsevier
Thrombopoietin (TPO) plays an important role in injuries of different tissues. However, the
role of TPO in acute pancreatitis (AP) is not yet known. The aim of the study was to …

Thrombopoietin as early biomarker of disease severity in patients with acute pancreatitis

E Lupia, L Pigozzi, E Pivetta, O Bosco, B Vizio… - Pancreas, 2017 - journals.lww.com
Objectives To study the concentrations of thrombopoietin (TPO), a growth factor recently
involved in the pathogenesis of experimental acute pancreatitis (AP), and its potential role …

Hepatic thrombopoietin mRNA is increased in acute inflammation

EM Wolber, J Fandrey, U Frackowski… - Thrombosis and …, 2001 - thieme-connect.com
The plasma concentration of thrombopoietin (TPO) in general is inversely related to the
mass of platelets and megakaryocytes. However, reactive thrombocytosis of inflammatory …

[HTML][HTML] Elevated thrombopoietin in plasma of burned patients without and with sepsis enhances platelet activation

E Lupia, O Bosco, F Mariano, AE Dondi, A Goffi… - Journal of Thrombosis …, 2009 - Elsevier
Background: Thrombopoietin (TPO) is a humoral growth factor that does not induce platelet
aggregation per se, but enhances platelet activation in response to several agonists …

Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation

H Burmester, EM Wolber, P Freitag… - Journal of interferon & …, 2005 - liebertpub.com
Clinical and laboratory studies indicate that thrombopoietin (TPO) gene expression
increases during inflammation. To clarify the role of interleukin 6 (IL-6) in this process, blood …

Thrombopoietin levels in sepsis and septic shock–a systematic review and meta-analysis

C Liu, D Görlich, CA Lowell, JE Italiano… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Sepsis is a life-threatening condition implicating an inadequate activation of the
immune system. Platelets act as modulators and contributors to immune processes. Indeed …

[HTML][HTML] Limited therapeutic efficacy of thrombopoietin on the regeneration of steatotic livers

K Abshagen, F Mertens, C Eipel… - International journal of …, 2013 - ncbi.nlm.nih.gov
Liver regeneration after partial hepatectomy is impaired in steatotic livers of leptin-deficient
ob/ob mice. Previous studies have shown that thrombopoietin (TPO) promotes liver …

Blockade of thrombopoietin reduces organ damage in experimental endotoxemia and polymicrobial sepsis

A Cuccurullo, E Greco, E Lupia, P De Giuli, O Bosco… - PLoS …, 2016 - journals.plos.org
Background and Purpose Thrombopoietin (TPO), a growth factor primarily involved in
thrombopoiesis may also have a role in the pathophysiology of sepsis. In patients with …

Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases

E Lupia, A Goffi, O Bosco… - Mediators of …, 2012 - Wiley Online Library
Thrombopoietin (TPO) is a humoral growth factor originally identified for its ability to
stimulate the proliferation and differentiation of megakaryocytes. In addition to its actions on …

Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirrhosis

T Ishikawa, T Ichida, Y Matsuda… - Journal of …, 2000 - Wiley Online Library
Abstract Background and Aims: The main causes of thrombocytopenia in cirrhosis are
thought to be platelet destruction and the reduction of thrombopoietin (TPO) expression in …