[HTML][HTML] International coordination of large-scale human induced pluripotent stem cell initiatives: Wellcome Trust and ISSCR workshops white paper

FAC Soares, M Sheldon, M Rao, C Mummery, L Vallier - Stem cell reports, 2014 - cell.com
There is growing recognition of the potential value of human induced pluripotent stem cells
(hiPSC) for understanding disease and identifying drugs targets. This has been reflected in …

[HTML][HTML] Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states

JH Lee, JB Lee, Z Shapovalova… - Nature …, 2014 - nature.com
Human-induced pluripotent stem cells (hiPSCs) provide an invaluable source for
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …

The human-induced pluripotent stem cell initiative—data resources for cellular genetics

I Streeter, PW Harrison, A Faulconbridge… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large
catalogue of human iPSC lines, arguably the most well characterized collection to date. The …

[HTML][HTML] Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming

S Ruiz, A Gore, Z Li, AD Panopoulos… - Nature …, 2013 - nature.com
Recent studies indicate that human-induced pluripotent stem cells contain genomic
structural variations and point mutations in coding regions. However, these studies have …

[HTML][HTML] Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives

KL Nazor, G Altun, C Lynch, H Tran, JV Harness… - Cell stem cell, 2012 - cell.com
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease
and development, drug discovery, and regenerative medicine. However, it is important to …

[HTML][HTML] Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions

J Wang, J Hao, D Bai, Q Gu, W Han, L Wang… - Stem cell research & …, 2015 - Springer
Introduction Human induced pluripotent stem cells (hiPSCs) are considered as one of the
most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials …

[HTML][HTML] Female human iPSCs retain an inactive X chromosome

J Tchieu, E Kuoy, MH Chin, H Trinh, M Patterson… - Cell stem cell, 2010 - cell.com
Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

[HTML][HTML] Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins?

KH Narsinh, J Plews, JC Wu - Molecular Therapy, 2011 - cell.com
© The American Society of Gene & Cell Therapy commentary hiPSCs has not yet been
undertaken. However, genetically matched comparison of murine iPSCs and ESCs recently …

Variability of human pluripotent stem cell lines

D Ortmann, L Vallier - Current opinion in genetics & development, 2017 - Elsevier
Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or
hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent …

The tumorigenic potential of pluripotent stem cells: What can we do to minimize it?

SE Peterson, I Garitaonandia, JF Loring - Bioessays, 2016 - Wiley Online Library
Human pluripotent stem cells (hPSCs) have the potential to fundamentally change the way
that we go about treating and understanding human disease. Despite this extraordinary …