[HTML][HTML] International coordination of large-scale human induced pluripotent stem cell initiatives: Wellcome Trust and ISSCR workshops white paper
There is growing recognition of the potential value of human induced pluripotent stem cells
(hiPSC) for understanding disease and identifying drugs targets. This has been reflected in …
(hiPSC) for understanding disease and identifying drugs targets. This has been reflected in …
[HTML][HTML] Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states
JH Lee, JB Lee, Z Shapovalova… - Nature …, 2014 - nature.com
Human-induced pluripotent stem cells (hiPSCs) provide an invaluable source for
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …
The human-induced pluripotent stem cell initiative—data resources for cellular genetics
I Streeter, PW Harrison, A Faulconbridge… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large
catalogue of human iPSC lines, arguably the most well characterized collection to date. The …
catalogue of human iPSC lines, arguably the most well characterized collection to date. The …
[HTML][HTML] Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming
S Ruiz, A Gore, Z Li, AD Panopoulos… - Nature …, 2013 - nature.com
Recent studies indicate that human-induced pluripotent stem cells contain genomic
structural variations and point mutations in coding regions. However, these studies have …
structural variations and point mutations in coding regions. However, these studies have …
[HTML][HTML] Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives
KL Nazor, G Altun, C Lynch, H Tran, JV Harness… - Cell stem cell, 2012 - cell.com
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease
and development, drug discovery, and regenerative medicine. However, it is important to …
and development, drug discovery, and regenerative medicine. However, it is important to …
[HTML][HTML] Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions
J Wang, J Hao, D Bai, Q Gu, W Han, L Wang… - Stem cell research & …, 2015 - Springer
Introduction Human induced pluripotent stem cells (hiPSCs) are considered as one of the
most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials …
most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials …
[HTML][HTML] Female human iPSCs retain an inactive X chromosome
J Tchieu, E Kuoy, MH Chin, H Trinh, M Patterson… - Cell stem cell, 2010 - cell.com
Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …
reorganization. It is unclear whether reprogramming of female human cells reactivates the …
[HTML][HTML] Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins?
KH Narsinh, J Plews, JC Wu - Molecular Therapy, 2011 - cell.com
© The American Society of Gene & Cell Therapy commentary hiPSCs has not yet been
undertaken. However, genetically matched comparison of murine iPSCs and ESCs recently …
undertaken. However, genetically matched comparison of murine iPSCs and ESCs recently …
Variability of human pluripotent stem cell lines
Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or
hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent …
hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent …
The tumorigenic potential of pluripotent stem cells: What can we do to minimize it?
SE Peterson, I Garitaonandia, JF Loring - Bioessays, 2016 - Wiley Online Library
Human pluripotent stem cells (hPSCs) have the potential to fundamentally change the way
that we go about treating and understanding human disease. Despite this extraordinary …
that we go about treating and understanding human disease. Despite this extraordinary …