The monooxygenase, peroxidase, and peroxygenase properties of cytochrome P450
EG Hrycay, SM Bandiera - Archives of biochemistry and biophysics, 2012 - Elsevier
This review examines the monooxygenase, peroxidase, and peroxygenase properties of
cytochrome P450 (P450) 1 enzymes and their mechanisms of action in archaeal, bacterial …
cytochrome P450 (P450) 1 enzymes and their mechanisms of action in archaeal, bacterial …
[图书][B] Monooxygenase, peroxidase and peroxygenase properties and reaction mechanisms of cytochrome P450 enzymes
EG Hrycay, SM Bandiera - 2015 - Springer
This review examines the monooxygenase, peroxidase and peroxygenase properties and
reaction mechanisms of cytochrome P450 (CYP) enzymes in bacterial, archaeal and …
reaction mechanisms of cytochrome P450 (CYP) enzymes in bacterial, archaeal and …
Oxidizing intermediates in cytochrome P450 model reactions
Oxoiron (IV) porphyrin π-cation radicals have been considered as the sole reactive species
in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin …
in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin …
Nucleophilicity of iron-peroxo porphyrin complexes
DL Wertz, JS Valentine - Metal-Oxo and Metal-Peroxo Species in Catalytic …, 2000 - Springer
For the past 20 years, cytochrome P450 researchers have sought to identify and to
characterize the reactive intermediates in reactions of these enzymes. This review focuses …
characterize the reactive intermediates in reactions of these enzymes. This review focuses …
Activation of molecular oxygen by cytochrome P450
The rich mechanistic enzymology of the cytochrome P450s has occupied chemists,
biochemists, pharmacologists, and toxicologists for over three decades. Are we near to a …
biochemists, pharmacologists, and toxicologists for over three decades. Are we near to a …
Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations
M Newcomb, PF Hollenberg, MJ Coon - Archives of biochemistry and …, 2003 - Elsevier
Cytochrome P450 enzymes catalyze a number of oxidations in nature including the difficult
hydroxylations of unactivated positions in an alkyl group. The consensus view of the …
hydroxylations of unactivated positions in an alkyl group. The consensus view of the …
Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates—the central bus station in heme oxygenase catalysis
Oxygen has always been recognized as an essential element of many life forms, initially
through its role as a terminal electron acceptor for the energy-generating pathways of …
through its role as a terminal electron acceptor for the energy-generating pathways of …
Model and enzymatic studies with cytochrome P-450
D Dolphin, BR James, T Leung - Inorganica Chimica Acta, 1983 - Elsevier
The cytochromes P-450 which have only been recognized for the past two decades are now
the most widely studied of all protiens. As is often the case with enzymes much of the …
the most widely studied of all protiens. As is often the case with enzymes much of the …
Alternatives to the oxoferryl porphyrin cation radical as the proposed reactive intermediate of cytochrome P450: two-electron oxidized Fe (III) porphyrin derivatives
Y Watanabe - JBIC Journal of Biological Inorganic Chemistry, 2001 - Springer
The active intermediates in most heme enzyme-catalyzed oxidations such as epoxidation
and hydroxylation have been attributed to the O= Fe (IV) porphyrin π-cation radical, so …
and hydroxylation have been attributed to the O= Fe (IV) porphyrin π-cation radical, so …
Reaction profile of the last step in cytochrome P-450 catalysis revealed by studies of model complexes
Z Gross, S Nimri, CM Barzilay, L Simkhovich - JBIC Journal of Biological …, 1997 - Springer
A series of oxoiron (IV) porphyrin cation radical complexes was investigated as compound I
analogs of cytochrome P-450. Both the spectroscopic features and the reactivities of the …
analogs of cytochrome P-450. Both the spectroscopic features and the reactivities of the …