Here, we provide data suggesting that the absence of silencing of the ectopic
reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells …

Reports on the retention of somatic cell memory in induced pluripotent stem cells (iPSCs)
have complicated the selection of the optimal cell type for the generation of iPSC biobanks …

To understand the mutational burden of human induced pluripotent stem cells (iPSCs), we
sequenced genomes of 18 fibroblast-derived iPSC lines and identified different classes of …

Variation in the differentiation capacity of induced pluripotent stem cells (iPSCs) to specific
lineages is a significant concern for their use in clinical applications and disease modeling …

Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine
and studies of disease and development. Somatic cell reprogramming involves epigenomic …

Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

The biomedical utility of induced pluripotent stem cells (iPSCs) will be diminished if most
iPSC lines harbor deleterious genetic mutations. Recent microarray studies have shown that …

Pluripotent stem cells derived from both embryonic and reprogrammed somatic cells have
significant potential for human regenerative medicine. Despite similarities in developmental …

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated
studies that contributed to our understanding of genetic influence on human traits. However …

Genome integrity of induced pluripotent stem cells (iPSCs) has been extensively studied in
recent years, but it is still unclear whether iPSCs contain more genomic variations than …