The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS
complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers …

Cumulative evidence indicates that MYC, one of the major downstream effectors of
NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) …

Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute
lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in …

NOTCH1 is frequently mutated in human precursor T-cell lymphoblastic leukemia/lymphoma
(pre-T LBL). In the current study, we found that 13 of 19 cell lines and 29 of 49 primary …

The Notch signaling pathway is a regulator of self-renewal and differentiation in several
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …

Notch signaling is a key developmental pathway that is subject to frequent genetic and
epigenetic perturbations in many different human tumors. Here we investigate whether long …

Notch signaling is a highly conserved cell–cell communication pathway regulating normal
development and tissue homeostasis. Aberrant Notch signaling represents an important …

Even if NOTCH1 is commonly mutated in chronic lymphocytic leukemia (CLL), its functional
impact in the disease remains unclear. Using CRISPR/Cas9-generated Mec-1 cell line …

Notch signaling plays a role in normal lymphocyte development and function. Activating
Notch1-mutations, leading to aberrant downstream signaling, have been identified in human …

Notch receptors have been implicated as oncogenic drivers in several cancers, the most
notable example being NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL). To …