Perturbations in neuronal protein homeostasis likely contribute to disease pathogenesis in
polyglutamine (polyQ) neurodegenerative disorders. Here we provide evidence that the co …

Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases
are characterized by neuronal accumulation of the disease protein, suggesting that the …

A major hallmark of the polyglutamine diseases is the formation of neuronal intranuclear
inclusions of the disease proteins that are ubiquitinated and often associated with various …

A common feature of many neurodegenerative diseases, including Alzheimer's and
Parkinsons's disease, the prion disorders, and the CAG repeat polyglutamine (polyQ) …

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative
diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the …

Neuronal loss and intraneuronal protein aggregates are characteristics of Huntington's
disease (HD), which is one of 10 known neurodegenerative disorders caused by an …

Intracellular inclusions are a unifying feature of polyglutamine (polyQ) neurodegenerative
diseases, yet each polyQ disease displays a unique pattern of neuronal degeneration. This …

Polyglutamine diseases are characterized by neuronal intranuclear inclusions of expanded
polyglutamine proteins, which are also ubiquitinated, indicating impairment of the ubiquitin …

The polyglutamine (polyQ) diseases are a group of nine fatal, adult-onset
neurodegenerative disorders characterized by the misfolding and aggregation of mutant …

Polyglutamine (polyQ) expansions cause neurodegeneration that is associated with protein
misfolding and influenced by functional properties of the host protein. The polyQ disease …