Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells
V van den Boom, M Rozenveld-Geugien… - Blood, The Journal …, 2013 - ashpublications.org
Abstract The Polycomb group (PcG) protein BMI1 is a key factor in regulating hematopoietic
stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the …
stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the …
Inner workings and regulatory inputs that control Polycomb repressive complex 2
MM O'Meara, JA Simon - Chromosoma, 2012 - Springer
Abstract Polycomb repressive complex 2 (PRC2) is a conserved multisubunit enzyme that
methylates histone H3 on lysine-27. This chromatin modification is a hallmark of target …
methylates histone H3 on lysine-27. This chromatin modification is a hallmark of target …
Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho
JL Brown, M Sun, JA Kassis - Proceedings of the National …, 2018 - National Acad Sciences
Polycomb group (PcG) proteins maintain the silenced state of key developmental genes in
animals, but how these proteins are recruited to specific regions of the genome is still poorly …
animals, but how these proteins are recruited to specific regions of the genome is still poorly …
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus
N Dietrich, AP Bracken, E Trinh, CK Schjerling… - The EMBO …, 2007 - embopress.org
The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is
often found deregulated in human cancer. The PcGs form two major protein complexes …
often found deregulated in human cancer. The PcGs form two major protein complexes …
Emerging roles for polycomb-group proteins in stem cells and cancer
Polycomb-group (PcG) complexes are multiprotein, evolutionarily conserved epigenetic
machineries that regulate stem cell fate decisions and development, and are also implicated …
machineries that regulate stem cell fate decisions and development, and are also implicated …
Polycomb repressor complex 2 in genomic instability and cancer
Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene
expression, and are widely recognized for their fundamental contributions to developmental …
expression, and are widely recognized for their fundamental contributions to developmental …
PRC2 facilitates the regulatory topology required for poised enhancer function during pluripotent stem cell differentiation
S Cruz-Molina, P Respuela, C Tebartz, P Kolovos… - Cell stem cell, 2017 - cell.com
Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in
the establishment of somatic expression programs during embryonic stem cell (ESC) …
the establishment of somatic expression programs during embryonic stem cell (ESC) …
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes. Emerging …
pluripotency by silencing lineage-specifying developmental regulator genes. Emerging …
Nascent RNA interaction keeps PRC2 activity poised and in check
Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of
chromatin domains repressive to transcription through catalysis of methylation of histone H3 …
chromatin domains repressive to transcription through catalysis of methylation of histone H3 …
Polycomb complexes redundantly maintain epidermal stem cell identity during development
Abstract Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic
developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and …
developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and …