Impact of regulatory variation across human iPSCs and differentiated cells
Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular
differentiation and cell types that are otherwise difficult to access. We investigated the use of …
differentiation and cell types that are otherwise difficult to access. We investigated the use of …
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency
Mammalian somatic cells can be directly reprogrammed into induced pluripotent stem cells
(iPSCs) by introducing defined sets of transcription factors. Somatic cell reprogramming …
(iPSCs) by introducing defined sets of transcription factors. Somatic cell reprogramming …
X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations
X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-
linked genes in female cells. We report that subcultures from lines of female human …
linked genes in female cells. We report that subcultures from lines of female human …
Reprogramming factor expression initiates widespread targeted chromatin remodeling
Despite rapid progress in characterizing transcription factor-driven reprogramming of
somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions …
somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions …
[HTML][HTML] Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
The developmental potential of human pluripotent stem cells suggests that they can produce
disease-relevant cell types for biomedical research. However, substantial variation has been …
disease-relevant cell types for biomedical research. However, substantial variation has been …
Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …
with a new cellular identity. However, the epigenetic events and molecular mechanisms …
[HTML][HTML] Epigenetics of reprogramming to induced pluripotency
Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner
with reprogramming factor binding, transcription, and chromatin states changing during …
with reprogramming factor binding, transcription, and chromatin states changing during …
Cellular metabolism and induced pluripotency
The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
The equivalence of human induced pluripotent stem cells (hiPSCs) and human embryonic
stem cells (hESCs) remains controversial. Here we use genetically matched hESC and …
stem cells (hESCs) remains controversial. Here we use genetically matched hESC and …