This study aimed to evaluate the usefulness of the dissolution/permeation system (D/P
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …

The present study aimed to develop and characterize new formulations of dipyridamole
(DP), a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …

It is our hypothesis that the presence of an absorptive sink for in-vitro dissolution
experiments is decisive to predict extent and duration of super-saturation of low soluble …

This study was undertaken to develop new dipyridamole (DP) formulations with acidic
microenvironmental pH-modifiers for improving dissolution and absorption under …

Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …

The aim of this study was to develop new dipyridamole (DP) salts with pH-independent
solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried …

Objective Most studies regarding acidifiers focused on their role in improving the dissolution
performance of a drug by altering the pH of the microenvironment. However, in the current …

A novel multicompartment dissolution system was developed by modifying a conventional
six‐vessel United States Pharmacopoeia dissolution system to study the dissolution and …

The aim of this study was to compare the oral absorption of two weak bases including their
pH-independent controlled-release preparations using an in vitro evaluation system. This …

The focus of in vitro dissolution testing during early development of modified release (MR)
formulations is to provide predictive estimates of drug release in respect to in vivo …