Dipyridamole (DPL) is a weakly basic BCS class II drug which precipitates upon entering
into intestine leading to pH dependant and variable absorption. Thus, research envisaged …

The effects of tablet preparation and subsequent film coating with amorphous solid
dispersion (ASD) particles that were composed of a drug with poor water solubility and …

Simple solvent shift is often used to induce supersaturation and investigate precipitation
kinetics in early drug development as a substitute for amorphous dissolution. This study …

Most of the drug discovered in past decade belongs to biopharmaceutical classification
system (BCS) class II. The solubility of these drugs is the limiting factor for oral …

Amorphous solid dispersions (ASD) are one of the most important supersaturating drug
delivery systems (SDDS) for poorly water-soluble drugs to improve their bioavailability. As a …

Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared
using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and …

Formulating drugs into amorphous solid dispersions (ASDs) represents an attractive means
to enhance the aqueous solubility of drugs. Furthermore, water-soluble polymers have …

In this study, the dissolution behaviour of dipyridamole (DPM) and cinnarizine (CNZ) spray-
dried amorphous solid dispersions (ASDs) using polyvinyl pyrrolidone (PVP) and polyacrylic …

The purpose of this study was to investigate the influence of gastric emptying patterns,
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …

Many upcoming drug candidates are pH-dependent poorly soluble weak bases in the pH
range of the gastrointestinal tract. This often leads to a high in vivo variability and …