Age-related misfolding and aggregation of pathogenic proteins are responsible for several
neurodegenerative diseases. For example, Huntington's disease (HD) is principally driven …

Aggregation-prone polyglutamine (polyQ) expansion proteins cause several
neurodegenerative disorders, including Huntington disease. The pharmacological activation …

Experiments in yeast have significantly contributed to our understanding of general aspects
of biochemistry, genetics, and cell biology. Yeast models have also delivered deep insights …

Proteins with expanded polyglutamine (poly Q) segments cause a number of fatal
neurodegenerative disorders, including Huntington's disease (HD). Previous high …

Protein misfolding is associated with many human diseases, particularly neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease 1 …

Huntington's disease (HD) typifies a class of inherited neurodegenerative disorders in which
a CAG expansion in a single gene leads to an extended polyglutamine tract and misfolding …

Studies of the mutant gene in Huntington's disease, and for eight related neurodegenerative
disorders, have identified polyglutamine (polyQ) expansions as a basis for cellular toxicity …

Polyglutamine (polyQ) expansion in many proteins, including huntingtin and ataxin‐3, is
pathogenic and responsible for neuronal dysfunction and degeneration. Although at least …

Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by
expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ …

Several neurodegenerative diseases, including Huntington disease (HD), are associated
with aberrant folding and aggregation of polyglutamine (polyQ) expansion proteins. Here we …