Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of
Huntington's disease and other polyQ disorders. Therefore, strategies aiming at restoring …

The inherited polyglutamine (polyQ) expansion diseases are characterized by progressive
accumulation of aggregation-prone polyQ proteins, which may provoke proteostasis …

Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Huntington's disease (HD) results from expansions of polyglutamine stretches (polyQ) in the
huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death …

In polyglutamine (polyQ) degeneration, disease protein that carries an expanded polyQ tract
is neurotoxic. Expanded polyQ protein exists in different conformations that display distinct …

Polyglutamine protein aggregates are a hallmark of several neurodegenerative diseases,
including Huntington's disease, and increasing evidence suggests that reducing or inhibiting …

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative
disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease …

The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases
that include Huntington's disease, various spinocerebellar ataxias, spinal and bulbar …

Polyglutamine diseases are a major cause of neurodegeneration worldwide. Recent studies
highlight the importance of protein quality control mechanisms in regulating polyglutamine …

Protein misfolding and the formation of aggregates are increasingly recognized components
of the pathology of human genetic disease and hallmarks of many neurodegenerative …