Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …

Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative
disorders. These diseases are normally characterized by progressive loss of neuron cells …

Background: Neurodegeneration is a condition in which progressive loss of function and
structure of neurons occurs. Several lines of evidence suggest that oxidative stress has a …

Significance: Production of pro-inflammatory and anti-inflammatory cytokines is part of the
defense system that mostly microglia and macrophages display to induce normal signaling …

Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …

Reactive oxygen species and oxidative state are slowly gaining acceptance in having a
physiological relevance rather than just being the culprits in pathophysiological processes …

Free radicals are generated as byproduct of our body metabolism, and their adverse effect
on normal functioning of our body is prevented by body's own antioxidant machinery. Any …

Reactive oxygen species are constantly produced in aerobic organisms as by-products of
normal oxygen metabolism and include free radicals such as superoxide anion (O 2−) and …

Reduction oxidation (redox) reactions are central to life and when altered, they can promote
disease progression. In the brain, redox homeostasis is recognized to be involved in all …

Oxidative stress is typically reported in neurodegenerative diseases. Although the
mechanisms underlying this condition are not completely understood, the brain appears …