With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC)
have generated enormous interest as agents of cell replacement therapy. One potential …

Human embryonic stem cells (hESCs) derived from human blastocysts have an apparently
unlimited proliferative capacity and can differentiate into ectoderm, mesoderm, and …

X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-
linked genes in female cells. We report that subcultures from lines of female human …

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female
human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon …

X chromosome inactivation (XCI) is a dosage compensation mechanism essential for
embryonic development and cell physiology. Human embryonic stem cells (hESCs) derived …

Inactivation of the X chromosome during early female development and the subsequent
maintenance of this transcriptionally inert state through countless cell divisions remain a …

Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly
from blastocysts, but their X chromosome state has remained unresolved. Here, we show …

The clinical and research value of human embryonic stem cells (hESC) depends upon
maintaining their epigenetically naïve, fully undifferentiated state. Inactivation of one X …

The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of
pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs (hESCs) …

Applications of embryonic stem cells (ESCs) require faithful chromatin changes during
differentiation, but the fate of the X chromosome state in differentiating ESCs is unclear …