Polyglutamine (polyQ) diseases represent a neuropathologically heterogeneous group of
disorders. The common theme of these disorders is an elongated polyQ tract in otherwise …

Age-related misfolding and aggregation of pathogenic proteins are responsible for several
neurodegenerative diseases. For example, Huntington's disease (HD) is principally driven …

Insoluble protein aggregates are consistently found in neurodegenerative disorders caused
by expanded polyglutamine [poly (Q)] repeats. The aggregates contain various components …

Background Polyglutamine expansion disorders are caused by an expansion of the
polyglutamine (polyQ) tract in the disease related protein, leading to severe …

Proteins with expanded polyglutamine (poly Q) segments cause a number of fatal
neurodegenerative disorders, including Huntington's disease (HD). Previous high …

The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the
pathogenesis of several neurodegenerative diseases, including Huntington's disease …

Understanding how proteins protect themselves from aberrant aggregation is of primary
interest for understanding basic biology, protein biochemistry, and human disease. We …

Abstract Spinocerebellar ataxia type 3 (SCA3) is the most common type of SCA worldwide
caused by abnormal polyglutamine expansion in the coding region of the ataxin-3 gene …

Protein misfolding is associated with many human diseases, including neurodegenerative
diseases, such as Alzheimer disease, Parkinson disease and Huntington disease. Protein …

Among the nine dominantly inherited, age-dependent neurodegenerative diseases caused
by abnormal expansion in the polyglutamine (polyQ) repeat of otherwise unrelated proteins …