Incorporation of weak acids as pH modifiers enhances the release of weakly basic drugs in
higher pH environments by reducing the microenvironmental pH (pHM). The objectives of …

Objective The aim of the current study was firstly to identify polymers which effectively inhibit
precipitation of Dipyridamole (DP), a poorly water-soluble basic drug, in neutral solution …

Coamorphization has been proven to be an effective approach to improve bioavailability of
poorly soluble active pharmaceutical ingredients (APIs) by virtue of solubilization, and also …

The purpose of this study was to investigate the influence of gastric emptying patterns,
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …

Several biologically relevant phospholipids were assessed as potential carriers/additives for
rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System …

The solubility of dipyridamole at pH 2.5 was about 6000-fold greater than that at pH 7.0. A
commercial powder of dipyridamole showed pH-dependent dissolution. Two kinds of …

Purpose The purpose of this work is to investigate the effect of microenvironmental pH
modulation on the in vitro dissolution rate and oral absorption of GDC-0810, an oral anti …

The oral bioavailability of poorly water-soluble active pharmaceutical ingredient (API) is
often inadequate for the desired therapeutic effect. Micro-environmental pH-modifying solid …

Objective: The objective of the present study is a determination of the limiting solubility of
dipyridamole in water and optimal ratios of polyethylene glycol: dipyridamole at which …

Importance of the field: Although the solid dispersion method has been known to increase
the dissolution rate of poorly water-soluble drugs by dispersing them in hydrophilic carriers …