Spray dried solid dispersion of repaglinide using hypromellose acetate succinate: in vitro and in vivo characterization
Objective This research study attempted to develop spray-dried solid dispersion, to enhance
the solubility of repaglinide, an antidiabetic drug. Significance Aqueous solubility plays a …
the solubility of repaglinide, an antidiabetic drug. Significance Aqueous solubility plays a …
[HTML][HTML] Dissolution of a biopharmaceutics classification system class ii free acid from immediate release tablets containing a microenvironmental pH modulator …
D Haznar-Garbacz, D Hoc, G Garbacz, M Lachman… - AAPS …, 2022 - Springer
Poor water dissolution of active pharmaceutical ingredients (API) limits the rate of absorption
from the gastrointestinal tract. Increasing the pH of a solid form microenvironment can …
from the gastrointestinal tract. Increasing the pH of a solid form microenvironment can …
Enhanced solubility through particle size control, modification of crystal behavior, and crystalline form changes in solid dispersion of nifedipine
The purpose of this study was to investigate the selectivity of polymers and the suitability of
spray drying to enhance nifedipine solubility. Nifedipine alone or in combination with …
spray drying to enhance nifedipine solubility. Nifedipine alone or in combination with …
Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach
Y Kojo, S Matsunaga, H Suzuki, H Sato, Y Seto… - European Journal of …, 2017 - Elsevier
The present study was aimed to evaluate the applicability of a self-micellizing solid
dispersion (SMSD) system of itraconazole (ITZ) with the use of Soluplus® to achieve …
dispersion (SMSD) system of itraconazole (ITZ) with the use of Soluplus® to achieve …
[HTML][HTML] Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers
Introduction: The main objective of this study was preparation and characterization of solid
dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion …
dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion …
Spray drying as a fast and simple technique for the preparation of extended release dipyridamole (DYP) microparticles in a fixed dose combination (FDC) product with …
H Hamishehkar, H Valizadeh, P Alasty… - Drug …, 2014 - thieme-connect.com
Recent advances have proven that the combinational therapy of extended release
dipyridamole (DYP) and fast release aspirin (ASP) can improve clinical indices of heart …
dipyridamole (DYP) and fast release aspirin (ASP) can improve clinical indices of heart …
Assessment of tailor-made HPMC-based matrix minitablets comprising a weakly basic drug compound
S Siepe, B Lueckel, A Kramer, A Ries… - Drug development and …, 2008 - Taylor & Francis
Tailor-made, pH-controlled matrix minitablets based on different HPMC types were
developed comprising the weakly basic drug dipyridamole. The incorporation of pH …
developed comprising the weakly basic drug dipyridamole. The incorporation of pH …
In vivo analysis of supersaturation/precipitation/absorption behavior after oral administration of pioglitazone hydrochloride salt; determinant site of oral absorption
Y Tanaka, M Sugihara, A Kawakami, S Imai… - European Journal of …, 2017 - Elsevier
The purpose of this study was to evaluate in vivo supersaturation/precipitation/absorption
behavior in the gastrointestinal (GI) tract based on the luminal concentration-time profiles …
behavior in the gastrointestinal (GI) tract based on the luminal concentration-time profiles …
Formulation design of an HPMC-based sustained release tablet for pyridostigmine bromide as a highly hygroscopic model drug and its in vivo/in vitro dissolution …
YT Huang, TR Tsai, CJ Cheng, TM Cham… - Drug development …, 2007 - Taylor & Francis
Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. A
sustained-release (SR) tablet prepared by direct compression of wet-extruded and …
sustained-release (SR) tablet prepared by direct compression of wet-extruded and …
Amorphous solid dispersions of carvedilol along with pH‐modifiers improved pharmacokinetic properties under hypochlorhydoria
S Halder, A Tabata, Y Seto, H Sato… - … & Drug Disposition, 2018 - Wiley Online Library
Carvedilol (CAR) belongs to biopharmaceutics classification system class‐II drugs, with poor
aqueous solubility and pH‐dependent solubility. The present study aimed to develop a …
aqueous solubility and pH‐dependent solubility. The present study aimed to develop a …