Dry powder inhalers (DPIs) are becoming increasingly popular in the treatment of both
systemic and pulmonary diseases. In an effort to enhance the DPIs, we developed spray …

This study described a pH-gradient dissolution method combined with flux measurements as
an in vitro tool for assessing the risk of bioavailability reduction due to drug-drug interactions …

A novel microdialysis-dissolution/permeation (MD/P) system was developed for the
biopharmaceutical assessment of oral drug formulations. This system consists of a side-by …

Dexibuprofen is a stronger non-steroidal anti-inflammatory drug than ibuprofen but with less
gastric damage. However, it suffers poor aqueous solubility. This work improved …

The present research was aimed at development and optimization of dipyridamole
gastroretentive microspheres. Gastro retention was achieved using swellable polymeric …

Drug release from polymeric matrix systems is the rate-limiting step for drug bioavailability
and is determined by drug solubility; most drugs show pH-dependent solubility. Polymeric …

Purpose The aim of the present study is to evaluate the formulation effect on the oral
absorption of poorly water-soluble drugs using a dissolution/permeation system (D/P …

The purpose was the evaluation of a new miniscale biphasic dissolution model with pH-shift
(miBIdi-pH). Its capability to predict supersaturation and precipitation of weak bases (eg …

Pyridostigmine bromide (PB) sustained-release (SR) pellets were developed by extrusion-
spheronization and fluid-bed methods using Taguchi experimental and 23 full factorial …

The aim of the study was to press a synergistic act of a formulation:(1) enhancing the
dissolution rate of a poorly water-soluble drug;(2) controlling the release rate of the drug …