The aim of this study was to compare the oral absorption of two weak bases including their
pH-independent controlled-release preparations using an in vitro evaluation system. This …

The aim of this work was to improve the solubility and dissolution rate of poorly-soluble,
weakly-basic, anti-emetic drug; domperidone (DMP) using solid dispersion technique …

Drug insolubility is one of the most intractable problems in new drug development and in
reformulation of existing medications. This chapter describes a novel approach, Insoluble …

The stability of solid dispersions (SD) during storage is of concern. We prepared the pH-
modulated SD (pSD) and compressed tablets consisting of polyethylene glycol (PEG) 6000 …

Dexibuprofen (DEXI) belongs to BCS class II drug with poor aqueous solubility resulting in
poor bioavailability. To enhance solubility and bioavailability of DEXI, DEXI-loaded solid …

Due to the instability of esomeprazole magnesium dihydrate (EPM), a proton pump inhibitor,
in gastric fluid, enteric-coated dosage form is commonly used for therapeutic application. In …

It is our hypothesis that the presence of an absorptive sink for in-vitro dissolution
experiments is decisive to predict extent and duration of super-saturation of low soluble …

In contrast to nifedipine matrix-based extended-release dosage forms, the osmotic pump
drug delivery systems have a zero-order drug release independent of external variables …

The roles of acidifiers in polyvinylpyrrolidone-based solid dispersions and physical mixtures
were originally investigated on dissolution rate of drug, acidifier release, structural …

Dipyridamole (DP) is an antiplatelet agent that shows decreased oral bioavailability with
increased gastric pH that occurs with commonly prescribed antacids. An extended‐release …