The purpose of this study was to evaluate the feasibility of using a counter polymer in
polyethylene oxide (PEO)/polyethylene glycol (PEG) polymeric matrices for the sustained …

The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the
drug development process. Following oral administration, drugs with slow dissolution rates …

Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared
using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and …

Repaglinide (RPG) is poorly water soluble drug BCS (Low solubility, High permeability). The
objective of this study was to enhance the dissolution of RPG for oral drug delivery. RPG …

Despite significant innovations in pharmaceutical industries, low water solubility is still a
common biopharmaceutics-related problem that encounters 40% of marketed …

The present work is a comparative study that matches between carriers and techniques
used to prepare solid mixtures with glimepiride. The study is directed towards elucidation of …

Over the last decades the poor solubility of new drugs has become an important issue, with
one of the main challenges being to develop oral dosage forms with acceptable …

Glimepiride is an effective oral hypoglycemic agent that lowers the glucose level of blood by
stimulating insulin release from beta cells of the pancreas. However, the poor aqueous …

Abstract DMHP (1, 2-dimethyl-3-hydroxy-pyrid-4-one) is an orally-active iron chelator that
has a short biological half-life and hence: a sustained-release formulation is currently being …

The objective of this study was to understand the impact of active pharmaceutical
ingredients (API) particle size on a re-developed generic product of glipizide and to improve …