Poorly water-soluble weakly basic compounds which are solubilized in gastric fluid are likely
to precipitate after the solution empties from the stomach into the small intestine, leading to a …

The purpose of this study was to investigate the efficiency of superdisintegrants in promoting
tablet disintegration and drug dissolution under varied media pH. Significant reductions in …

The aim of the study was to investigate caffeine release in fed and fasted state media from
three controlled release matrix tablets containing different HPMC viscosity grades. The …

Importance of the field: In formulation development, weakly acidic or basic drugs pose a
major challenge as the solubility depends significantly on pH of the dissolution media. This …

The purpose of this research was to investigate drug dose, solubility, permeability, and their
interplay, as key factors in oral formulation development for lipophilic drugs. A PEG400 …

The present study aimed to improve solubility and prolong the release duration of a poorly
soluble drug using a combination of two different types of formulations (solid dispersion and …

Objective: Divalproex sodium (DVS) is a challenging drug owing to its hygroscopicity, bitter
taste, and short in vivo half-life. This study aims to produce stable taste masked DVS once …

Oromucosal delivery, especially that utilising the buccal and sublingual mucosa as the
absorption site, is a promising drug delivery route which promotes rapid absorption and high …

Introduction: This research focuses on development and optimization of dipyridamole (DPM)
gastroretentive (GR) floating matrix tablets through risk-based approach using combination …

The aim of this study was to develop photostable gastro retentive formulation for nifedipine
loading into low-density polypropylene microporous particles (Accurel MP 1000®) by a …