Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly
from blastocysts, but their X chromosome state has remained unresolved. Here, we show …

Applications of embryonic stem cells (ESCs) require faithful chromatin changes during
differentiation, but the fate of the X chromosome state in differentiating ESCs is unclear …

The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of
pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs (hESCs) …

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female
human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon …

In mammals, X chromosome inactivation (XCI) is a process in which one of the two X
chromosomes is silenced, following XIST expression. Mouse female pluripotent stem cells …

Dosage compensation of sex-chromosome gene expression between male and female
mammals is achieved via X chromosome inactivation (XCI) by employing epigenetic …

Human embryonic stem cells (hESCs) derived from human blastocysts have an apparently
unlimited proliferative capacity and can differentiate into ectoderm, mesoderm, and …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC)
have generated enormous interest as agents of cell replacement therapy. One potential …

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of
gene expression, wherein the long non-coding RNA XIST spreads across the X …