Incorporation of weak acids as pH modifiers enhances the release of weakly basic drugs in
higher pH environments by reducing the microenvironmental pH (pHM). The objectives of …

For weakly basic drugs, pH-dependent solubility characteristics can translate into low and
incomplete release of these drugs from sustained release formulations. The objective of this …

Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions,
which can result in low and incomplete release of these drugs from sustained release …

Weakly basic drugs or salts thereof demonstrate pH-dependent solubility. The resulting
release from conventional matrix tablets decreases with increasing pH-milieu of the …

The rate and extent of drug release from most controlled release systems are influenced by
the pH of the dissolution medium for drugs with pH-dependent solubility. This dependency of …

Tailor-made, pH-controlled matrix minitablets based on different HPMC types were
developed comprising the weakly basic drug dipyridamole. The incorporation of pH …

Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …

One method of achieving sustained drug release is by the use of hydrophilic polymeric
excipients directly compressed with active ingredients into tablets. Hydrophilic polymers …

The solubility of weakly basic drugs within passage though GI tract leads to pH-dependent
or even incomplete release of these drugs from extended release formulations and …

There are many reports in the literature referring to the effect of 'microenvironmental pH'on
solid dosage form performance, particularly stability and dissolution profiles. Several …